Frog Skin Fights Depression: Psychedelic Compound Without the Trip
Harvard researchers isolated a non-hallucinogenic version of bufotenin from Rhinella marina toad skin that works as fast-acting antidepressant. The Cell journal study shows:
Science Breakthrough
- Targets 5-HT1A receptors without activating 5-HT2A (no psychedelic effects)
- Stimulates neurogenesis: 50% higher than SSRIs in mouse models
- Rapid action: Effects in hours vs weeks
Clinical Potential:
| Advantage | Traditional SSRIs | Toad Compound |
|---|---|---|
| Speed | 4-6 weeks | 2 hours |
| Side Effects | Weight gain | Mild nausea |
| Neuroplasticity | Moderate | High |
Ethical Note:
"Synthetic version will prevent ecological harm", assures Dr. Emily Tran.
Would you try a toad-derived antidepressant? Share your thoughts or tag a neuroscience friend!

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