Frog Skin Fights Depression: Psychedelic Compound Without the Trip




Harvard researchers isolated a non-hallucinogenic version of bufotenin from Rhinella marina toad skin that works as fast-acting antidepressant. The Cell journal study shows:

Science Breakthrough

  • Targets 5-HT1A receptors without activating 5-HT2A (no psychedelic effects)
  • Stimulates neurogenesis: 50% higher than SSRIs in mouse models
  • Rapid action: Effects in hours vs weeks

Clinical Potential:

AdvantageTraditional SSRIsToad Compound
Speed4-6 weeks2 hours
Side EffectsWeight gainMild nausea
NeuroplasticityModerateHigh

Ethical Note:

"Synthetic version will prevent ecological harm", assures Dr. Emily Tran.

Would you try a toad-derived antidepressant? Share your thoughts or tag a neuroscience friend!


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